Unlocking melanoma’s cellular mosaic for immunotherapy

Melanoma cells move along a transcriptomic continuum of lineage-specific cell states. 

Melanoma cells can also turn on various extrinsic transcriptomic meta-programs.

The tumor microenvironment shapes this complex transcriptomic landscape both at cell state and meta-program levels.

Rewiring the melanoma transcriptomic landscape is one promising strategy to overcome resistance to immune checkpoint blockade (ICB).

https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00032-7

https://sciencemission.com/melanoma%E2%80%99s-cellular-mosaic