Time-of-day dependency of adoptive cell therapies
The tumor vasculature and adoptively transferred T cells express adhesion and chemokine receptors in a rhythmic fashion that strongly impacts T cell tumor infiltration.
Circadian control over T cell activation and phenotype may contribute to the antitumor response of adoptive cell therapies performed in the clinic.
Timing adoptive cell therapy delivery to align with circadian rhythms at the early behavioral active phase may improve tumor control and reduce adverse effects in the clinic.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(25)00154-2
