The dynamics of plasma membrane repair
Plasma membrane (PM) wounding triggers the immediate recruitment of Ca2+-activated proteins and exocytic membrane addition leading to tension reduction and wound closure, namely resealing.
Resealing is followed by PM remodeling that involves upregulation of endocytosis, tension restoration, and recruitment of remodeling-associated proteins, namely restructuring. Following resealing and restructuring, long-term processes such as replenishment of the repair machinery are induced in the later stage of repair, namely restoration.
The kinetics of the various PM repair responses should be tracked at the wound site following damage to identify their roles in the different phases of repair.
Differences in repair mechanisms are not due to wound source or cell type, and instead point to varying repair demands during different temporal stages of PM wound repair.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00115-1
