Human stem cell models to evaluate role of oligodendrocytes in ALS
Oligodendrocytes and oligodendrocyte progenitor cells play critical roles in central nervous system function, in part, through crosstalk with neurons and other glial cells.
Oligodendrocyte lineage cell and glial crosstalk dysfunction have been increasingly implicated in disease, with disease associated oligodendrocytes emerging as new players across injury and neurodegeneration.
Cells in the oligodendrocyte lineage have been implicated in the initiation and progression of amyotrophic lateral sclerosis in both animal models and human postmortem tissue.
Use of human induced pluripotent stem cell-derived multicellular cultures provide access to the study of oligodendrocytes and their interactions in patient-derived cells.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00251-X
