Interplay between mesothelial and immune cells in the tumor microenvironment

Mesothelial cells (MCs) exhibit a dual role in malignant tumors of the thoracic and abdominal peritoneum because they can either promote or inhibit tumor progression, likely owing to their heterogeneity. 

Single-cell sequencing technology has provided deeper insights into the characterization and functional study of MCs in the tumor microenvironment (TME).

MC–immune cell interactions in the TME enable cancer cells to evade immune surveillance, thereby promoting tumor progression and drug resistance.

Targeting MCs for immunotherapeutic strategies may enhance antitumor immunity in the TME, and this represents a promising clinical treatment approach.

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(25)00086-3

https://sciencemission.com/Mesothelial-and-immune-cells-interplay-in-the-TME