Branched-chain amino acid transaminases in tumor therapy
Branched-chain amino acid transaminases (BCATs) like BCAT1 and BCAT2, regulate branched-chain amino acid (BCAA) metabolism and influence critical oncogenic pathways, play critical roles in tumorigenesis and therapeutic resistance in various cancers.
In addition, BCATs modulate metabolism, modify epigenetics, and support tumor immune evasion and thus may act as biomarkers and therapeutic targets.
Overexpression expression of BCATs in many cancers is linked to resistance to various therapies and thus targeting BCATs may help to overcome drug resistance and improve treatment outcomes.
The researchers in this review examine the mechanisms of BCATs in cancer progression and resistance and their therapeutic potential.
https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1712076/full
