Celastrol prevents aging-related sarcopenia and mitochondrial dysfunction

Age-related loss of skeletal muscle is termed sarcopenia and is associated with mitochondrial dysfunction.

Although exercise has been shown to mitigate muscle aging through activation of peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α)-dependent mitochondrial biogenesis and oxidative metabolism, researchers are working at the pharmacological intervention since the frailty of the condition may not allow the patients to stick to the exercise regimen.

The researchers identified celastrol as a PGC-1α inducer or exercise mimetic in transcriptomic drug screen.

They show that celastrol potentiated myogenic differentiation and mitochondrial bioenergetic in cultured  cells and young mice and extended the life span. It also muscle decline and mitochondrial dysfunction in aging mice.

https://www.sciencedirect.com/science/article/pii/S2090123226001074

https://sciencemission.com/therapeutic-agent-against-aging-related-sarcopenia