Cellular reprogramming for tissue rejuvenation!
Partial cellular reprogramming reverses age-associated epigenetic marks and restores transcriptional profiles without inducing pluripotency.
Transient OSKM (OCT4, SOX2, KLF4 and MYC) expression rejuvenates multiple tissues in vivo, enhancing regeneration and extending lifespan in both progeroid and naturally aged models.
Chemical reprogramming mimics genetic approaches, reducing senescence and oxidative stress while preserving somatic identity.
Tissue-specific protocols demonstrate functional recovery in the brain, liver, muscle, and skin, with reduced fibrosis and inflammation.
Advances in delivery vectors, small molecule cocktails, and temporal control are enabling safer, clinically relevant rejuvenation strategies.
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(26)00011-0
