Histamine 2 receptor in attention-deficit/hyperactivity disorder
Inattention, hyperactivity, and impulsivity are characteristics of attention deficit hyperactivity disorder (ADHD) but the neurophysiological mechanisms are not well understood.
The researchers discovered that deficiency of histamine H2 receptor (H2R) in parvalbumin-positive neurons in substantia nigra pars recticulata (PVSNr) attenuates PV+ neuronal activity and induces hyperactivity, impulsivity, and inattention.
The authors discovered decreased H2R expression was observed in PVSNr in patients with ADHD symptoms and dopamine-transporter-deficient mice.
The researchers demonstrate that H2 receptor in PVSNr regulates attention, impulsivity, and motion via distinct efferents and H2 receptor agonist can alleviate behavioral abnormalities in an ADHD mice model.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00096-5
https://sciencemission.com/Histamine-2-receptor-and-attention-deficit-disorder
