Circadian clock role in transcription-coupled DSB repair

Transcription-coupled DSB repair (TC-DSBR) pathway is involved in the repair of DNA double-strand breaks (DSBs) produced in transcriptionally active chromatin. 

The researchers show that DSBs in transcribed loci in human cells are relocated and tethered to the nuclear envelope in a manner that depends on PER2, a protein of the PERIOD complex involved in the circadian clock.

This mechanism contributes to homologous recombination repair, fosters RAD51 assembly, prevents DSB clustering and counteracts translocation frequency.

https://www.cell.com/molecular-cell/fulltext/S1097-2765(25)00868-8

https://sciencemission.com/Circadian-PERIOD-proteins-regulate-TC-DSB-repair