Circular RNAs in therapeutics!
Over the past decade, research into circular RNA (circRNA) has increased rapidly, and over the past few years, circRNA has emerged as a promising therapeutic platform.
CIrRNAs have unique circular structure in which the 5′ and 3′ ends are covalently linked to form a closed loop.
CircRNAs play a key role in regulating protein and RNA functions. Due to increased stability and a favorable immunological profile compared with mRNAs, circRNAs make attractive candidates for RNA-based therapies.
In this review the authors describe the properties of circRNAs, their therapeutic potential and technologies for their synthesis.
They also discuss the prospects and challenges to be overcome to unlock the full potential of circRNAs as drugs.
