Controlling dendritic branching
The complex structure of the nervous system depends on the complexity and control of the dendritic branching.
The researchers demonstrate that the kinetochore protein KNL-1 and its associated KMN (Knl1/Mis12/Ndc80 complex) network partners control dendrite branching.
KNL-1 prevents premature neurodegeneration by restraining excess dendritic branching and promoting contact-dependent repulsion events.
They show that KNL-1 loss cause significant alterations of the actin cytoskeleton alongside changes in microtubule dynamics within dendrites.
https://rupress.org/jcb/article/224/2/e202311147/277134/The-kinetochore-protein-KNL-1-regulates-the-actin
