Cuproptosis mechanism in cancer!
As a copper-dependent regulated form of cell death, cuproptosis is critically important for developing targeted cancer therapies and overcoming drug resistance.
A multidimensional framework deciphers the physiological regulation of copper homeostasis, including hepatocentric organ-level regulation, organelle-specific cellular storage and transport, and iron– copper–zinc ion crosstalk.
Cuproptosis is mainly regulated by core cuproptosis proteins, mitochondrial respiratory function, and cellular copper homeostasis.
By depleting glutathione (GSH), alleviating hypoxia, modulating immunity, and enabling multimodal synergy, innovative copper-based nanomaterials enhance copper ion delivery and cytotoxicity, resulting in potent antitumor effects.
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(26)00037-4
