Developmental robustness using optimality
Understanding the robustness of complex traits in vivo is challenging due to inherent stochastic behavior and difficulties in capturing variabilities across scales.
Advances in quantitative methods have improved our ability to analyze biological variability and gain deeper insights into developmental processes.
Feedback mechanisms operating at the molecular, cellular, and tissue levels can ensure robustness in embryonic patterning.
In developing tissues lacking feedback (regulatory mechanisms that control responses) and plasticity (capacity for alternative developmental outcomes), coupling of key parameters through evolutionary adaptation can confer developmental robustness.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00204-1
