Dysregulated propionate metabolism and methylmalonic acid in metabolic disease, aging, and cancer
Various diseases like cardiovascular and renal diseases, obesity, diabetes, aging, and cancer linked to dysregulation in propionate metabolism.
Inborn errors of metabolism like methylmalonic and propionic acidemias results from mutations in propionic acid metabolic pathway.
The authors in this review summarize alterations in the pathway and associated metabolites that are involved in the development of various metabolic diseases and link aging to cancer progression and metastasis.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00005-1
https://sciencemission.com/dysregulated-propionate-metabolism
