Ependymal motile cilia defects are implicated in multiple sclerosis
Ependymal cells with cilia are critical for circulating CSF solutes and regulating local fluid flow.
The researchers carried out single cell RNA sequencing analysis of human ependymal cells in MS and demonstrated largescale dysregulation of ciliary genes. They also find that motile cilia on epithelial cells lining the brain ventricles are disrupted in MS.
The analysis of ependymal cells in EAE also demonstrated altered cilia gene and protein expression.
Using patient tissue and animal models, they link ciliary dysfunction to inflammation and periventricular pathology.
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awaf440/8340874
