Extracellular vesicles to treat neurodegenerative disorders

Extracellular vesicles (EVs) derived from mesenchymal stromal cells (MSCs) represent a promising therapeutic tool to treat the complex pathology of neurodegenerative diseases. MSC-EVs can deliver molecules to the brain, opening new possibilities for targeted therapeutic delivery. 

MSC-EVs modulate neuroinflammation by shifting immune cells toward antiinflammatory states, a key mechanism in slowing disease progression.

Clinical translation of MSC-EV-based treatment strategies is challenged by variability in MSC sources and limited scalability, raising the need for more standardized production methods.

Advances in EV engineering may enhance brain targeting and drug loading, increasing the therapeutic potential of MSC-EVs and moving the field closer to clinical application.

https://www.cell.com/trends/neurosciences/fulltext/S0166-2236(25)00194-8

https://sciencemission.com/extracellular-vesicles-as-immune-modulators