In vivo transient reprogramming to expands neocortex and protects from neurodegeneration
The researchers report on using Yamanaka factors (YFs) for partial reprogramming in the mouse brain. During development, YF induction results in cortical expansion and improved behavior.
Similar induction at adult stages prevents the development of several Alzheimer’s disease hallmarks.
These findings reveal YFs as a tool to increase neural proliferation and their potential use in brain disorders.
https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(24)00327-8
