Regulating macrophages and inflammation by three Krebs cycle-linked metabolites
Immune response involves reprogramming of metabolic pathways and processes in immune cells. These metabolic adaptations result in accumulation of metabolic intermediates that drive immune cell function and inflammation.
Three metabolites of Krebs cycle, itaconate, succinate, and fumarate have been shown to regulate multiple processes in macrophages.
The researchers discuss recent progress on these 3 metabolites with regard to their effect on macrophages in host defense and inflammatory diseases.
They also looked into the therapeutic opportunities presented from the mimicry of these metabolites or by targeting the enzymes that make or metabolize them in order to leverage the body’s own anti-inflammatory response.
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(25)00107-X
