Lipotoxicity-driven metabolic dysfunction-associated steatotic liver disease (MASLD)
Metabolic dysfunction-associated steatotic liver disease (MASLD) is currently the most prevalent liver disease worldwide.
Fat accumulation in the liver sets the ground for disease development and progression.
Lipotoxicity is one of the major phenomena associated with MASLD pathogenesis.
Different type of lipids may trigger different effects during MASLD, exerting cell-specific effects.
Lipid-induced cell death occurs though different mechanisms (apoptosis, necroptosis, pyroptosis and/or ferroptosis).
https://www.atherosclerosis-journal.com/article/S0021-9150(24)01225-5/fulltext
