Microbiota for cancer metastasis therapy
Metastatic cancers exhibit tumor typespecific gut microbiota profiles, yet universally show reduced microbial diversity compared with non-metastatic cancers.
Metastasis-associated microbiota appear to derive from primary tumors and actively participate in metastatic dissemination through multiple mechanisms.
Microbiota and their metabolites are closely involved in metastatic steps, including epithelial–mesenchymal transition, pre-metastatic niche formation, circulating tumor cell biology, and tumor microenvironment remodeling.
Targeting the microbiota and its metabolites offers transformative therapeutic opportunities to enhance treatment efficacy, reduce side effects, and overcome drug resistance in metastatic cancers.
https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(25)00217-5
