Mitochondrial dysfunction in brain aging
Alteration in brain energy metabolism and contribution of mitochondria in brain energy homeostasis is very well documented.
In addition to age-related mitochondrial decline in neurons, glial and vascular cells also exhibit distinct mitochondrial impairments in aging.
The researchers in this review discuss mitochondrial dysfunction across specific brain regions and diverse cell types, and highlighting subcellular compartmentalization and metabolic rewiring.
They also evaluate the role of mitochondrial transfer both in terms of metabolic cooperation between the cells and as therapeutics.
The authors also describe the clinical trials aimed at improving the brain function in older adults using mitochondria-targeted interventions.
