Mitochondrial supercomplexes assembly in exercise
The function of supercomplexes (SCs) formed from mitochondrial electron transport chain (ETC) is not well understood.
The researchers demonstrate that exercise dynamically modulates the assembly of mitochondrial respiratory complexes into supercomplexes (SCs) in human skeletal muscle, with this remodeling being sex dependent.
The authors found that males increased the assembly of complex III (CIII) into SCs, particularly high molecular weight SCs (HMWSCs), in an intensity-dependent manner within skeletal muscle. Females showed a stable content of both HMWSCs and I+III2 SCs during exercise.
This highlights the importance of accounting for biological sex when studying mitochondrial adaptations to exercise.
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00295-0
https://sciencemission.com/mitochondrial-supercomplexes-and-exercise
