Neurodegeneration independent of complement C3aR

Complement activation in the brain can contribute to neurodegeneration in response to Tau or other pathologies. 

The researchers show that deletion of the complement receptor C3aR does not protect against Tau-related neurodegeneration, microglia activation markers, or behavioral abnormalities in tauopathy.

The authors also found that C3aR KO did not impact endotoxemia-induced gene expression changes in microglia, astrocytes, and oligodendrocytes.

The study indicate that complement driven neurodegeneration occurs through C3aR-independent mechanisms.

https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00391-8

https://sciencemission.com/C3aR-deletion-does-not-attenuate-degeneration