Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson’s disease

Although association between oligodendrocytes and PD progression is very well established, yet how oligodendrocytes regulate the pathogenesis of PD is still unknown.

The researchers identify that oligodendrocytes drive PD-like neurodegeneration via the prosaposin-GPR37-IL-6 axis.

GPR37 is upregulated in oligodendrocytes, and prosaposin secretion is increased in parkinsonian mice.

Released prosaposin could induce IL-6 upregulation and secretion from oligodendrocytes by GPR37 signaling, resulting in enhanced neuroinflammation, dopamine neuron degeneration, and behavioral deficits.

GPR37 deficiency in oligodendrocytes prevents neurodegeneration in multiple PD models and the hallmarks of the PSAP-GPR37-IL-6 axis were observed in patients with PD.

https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00037-3

https://sciencemission.com/Oligodendrocytes-drive-neuroinflammation-and-neurodegeneration