Pills may not fully replace exercise!
Physical exercise plays an important role in primary and secondary cardiovascular disease prevention through its multisystemic effects.
Some pharmacological and phytochemical agents are potential ‘exercise mimetics’, capable of improving cardiometabolic health whether used alone or in combination with exercise.
‘Multi-omic’ approaches can help to identify potential exercise mimetics that mediate the cardiometabolic benefits of exercise.
The bulk of the evidence comes from preclinical research. More data are needed in humans, particularly with respect to safety and dosage.
The multisystemic benefits effects of exercise and the unique exercise milieu itself are difficult to mimic in a pill.
No pill is expected to fully replace exercise in the foreseeable future.
https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(25)00151-1
