Shaping the cancer epigenome with structural variation
Structural and epigenetic variation of the genome reciprocally regulate each other as part of cancer pathophysiology.
New technologies, such as long-read whole-genome, single-cell, and multiomic sequencing strategies, have created new opportunities for research examining the interplay between structural variation (SV) and epigenetics in malignancy.
SV, including extrachromosomal DNA (ecDNA), can increase enhancer activity and mobility.
Oncogenic viral integration is associated with disruptions to the local methylome.
Chromatin architecture is impacted by large-scale SV in malignancy.
https://www.cell.com/trends/cancer/fulltext/S2405-8033(25)00229-8
