Targeting hepatocyte-mediated crosstalk in liver fibrosis

Hepatocytes are central drivers of liver fibrosis. They mediate pathological intercellular crosstalk that initiates and promotes disease progression. 

During liver fibrosis, hepatocytes undergo cellular stress, metabolic dysregulation, and cell death. Key regulators such as hepatocyte nuclear receptors, cytokines, and miRNAs modulate these pathways through intercellular communication.

Insights into hepatocyte-related pathways provide valuable strategies for developing antifibrotic therapies, some of which have shown promising therapeutic outcomes in clinical trials.

In clinical practice, limitations such as adverse effects and suboptimal efficacy can be alleviated through combination therapies and drug modifications.

https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(26)00014-3

https://sciencemission.com/chaperone-mediated-autophagy-20983