Targeting myeloid cells in the central nervous system

Different compartments of the central nervous system (CNS) hosts distinct immune cell populations, such as monocytes and diverse macrophages, which play critical roles in local tissue homeostasis and regional disease pathogenesis. 

This review summarizes the latest approaches for modulating myeloid cell subsets in a compartment-specific manner, including cellular strategies such as stem cell therapy, ex vivo gene treatment, bone marrow transplantation, as well as non-cellular strategies like antibodies, small molecules, and viral gene delivery to augment CNS immune responses and improve disease outcomes.

The researchers also discuss the challenges encountered in translating targeting strategies from mice to humans.

https://www.cell.com/immunity/fulltext/S1074-7613(25)00135-9

https://sciencemission.com/targeting-of-myeloid-cells-in-the-CNS