The endoplasmic reticulum as a cradle for virus and extracellular vesicle secretion
Endoplasmic reticulum (ER)-associated proteins are increasingly reported to play an active role during extracellular vesicle (EV) secretion, in particular upon cellular stress.
Viruses have evolved sophisticated strategies to hijack ER-associated proteins to foster their replication, assembly, and release.
Secretion of EVs and viruses is tightly correlated, and the role of ER associated proteins in this ménage-àtrois necessitates further research.
https://www.cell.com/trends/cell-biology/abstract/S0962-8924(24)00250-2
