Tregs heterogeneity, mechanisms in T1DM
The phenotypic and functional characteristics of regulatory T cells (Tregs) are dynamically altered across different stages of type 1 diabetes mellitus (T1DM) progression.
Understanding the genetic and epigenetic mechanisms that drive Treg dysfunction offers novel therapeutic strategies for T1DM.
The network between Tregs and immune cells deepens our understanding of immune regulation in the context of T1DM, and may provide more feasible immunotherapeutic targets for patients with T1DM.
Chimeric antigen receptor (CAR)-Tregs targeting islet antigens demonstrate preclinical efficacy in delaying autoimmune diabetes onset but face challenges in clinical settings.
Optimization of clinical protocols and the application of biomarkers should enhance the clinical outcomes for T1DM patients.
https://www.cell.com/trends/pharmacological-sciences/fulltext/S0165-6147(25)00180-4
