Trophoblast stem cells from patients for placental medicine

Patient-specific trophoblast stem cells expand the genetic diversity represented by bona fide human trophoblast stem cell lines. 

The preservation of genetic and epigenetic backgrounds in patient-specific trophoblast stem cells varies depending on the derivation method.

Patient-specific trophoblast stem cells can be established through the transdifferentiation of induced pluripotent stem cells, direct induction from fibroblasts, derivation from cytotrophoblasts after pregnancy, or from chorionic villi collected via chorionic villus sampling during early pregnancy.

Chorionic villus-derived trophoblast stem cells can be established without terminating pregnancy and can be integrated with prospective clinical data for research and clinical applications.

Patient-specific trophoblast stem cells can be used to investigate the pathogenesis of placental disorders, predict individual risk, and develop personalized therapeutic strategies.

https://www.cell.com/trends/molecular-medicine/fulltext/S1471-4914(26)00039-0

https://sciencemission.com/trophoblast-stem-cells-for-placental-medicine