How artificial sweeteners impact the microbiome

Artificial sweeteners have been shown to impact the human gut microbiome to varying levels, with saccharin having the most pronounced effect, influencing the human glycemic response via gut microbiome dysbiosis. 

At environmentally relevant concentrations, a range of artificial sweeteners have been shown to impact bacterial conjugation and natural transformation.

Several artificial sweeteners have been shown to inhibit bacterial growth, including the growth of multidrug-resistant pathogens.

Certain artificial sweeteners, such as Ace-K and saccharin, have also shown antivirulence potential by inhibiting biofilm formation and increasing antibiotic susceptibility, highlighting their therapeutic potential.

https://www.cell.com/trends/microbiology/fulltext/S0966-842X(26)00010-7

https://sciencemission.com/artificial-sweeteners-on-bacterial-physiology