Regulation of cGAS–STING signalling
Pathogenic DNA and host-derived DNA are identified by cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signalling pathway. Being part of the innate immune system, this pathway plays an important role in antimicrobial defence, inflammatory disease, ageing, autoimmunity and cancer.
This review discuss the regulation of cGAS–STING signalling by both activating and inhibitory factors.
They also discuss the crosstalk between cGAS–STING signalling and other signalling pathways and a variety of cellular processes in which cGAS–STING signalling is involved, including autophagy, metabolism, ageing, inflammation and tumorigenesis.
