Role of centrosome in cancer
Several types of centrosome defects have been reported in cancer. These include extra centrosomes (centrosome amplification), centrosome loss, and defects in centriolar structure and pericentriolar material organization.
Centrosome amplification has been associated with chromosome instability in cancer and shown to directly promote aneuploidy.
Recent work has established the broad impact of these abnormalities in cancer through autonomous and nonautonomous mechanisms, leading to increased migration and invasion capacity, as well as to defects in cellular organization, secretion, immune regulation, and response to chemotherapy.
In mouse and cell models of cancer, centrosome amplification can both promote and decrease tumorigenesis, underscoring the importance of context-dependency and tolerance to these abnormalities.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00043-1
