Molecular condensates at the synapse for neurotransmission
Dynamic reorganization of synaptic vesicles, synapsins, and actin is tightly associated with synaptic activity, but the molecular details of their interactions are not fully understood.
This study shows how condensation of synapsin-1 and synaptic vesicles controls actin polymerization at the presynapse, enabling the synaptic vesicle clustering required for synaptic function.
The researchers show that synaptic vesicle-synapsin-1 condensates coordinate actin polymerization. They also demonstrate that the phosphorylation pattern of synapsin-1 regulates synapsin-actin assemblies.
The authors discover that actin forms toruses at the interface of synaptic vesicle condensates in vitro and in living synapses and the synapses lacking synapsins exhibit defects in presynaptic actin levels and organization.
https://www.embopress.org/doi/full/10.1038/s44318-025-00516-y
