Gut microbiota and type-2 diabetes risk in youth
Young people with type-2 diabetes is exploding globally.
The researchers in this review describe the risk factors and mechanisms underlying T2D pathogenesis in children and young people and current evidence connecting gut microbiota to stages of disease progression and treatment opportunities.
The authors also note that gut microbiota is established within the first few years of life, and that early environmental changes can steer microbiota toward a more resilient community to reduce metabolic risk. The author says that reading about research on these environmental factors increased her awareness of the social dimension of health in diabetes development.
The team says a better understanding of how genetic and environmental factors that lead to obesity also alter the make-up and function of the gut microbiota will yield better interventions for children most at risk for youth-onset diabetes.
https://www.cell.com/cell-reports-medicine/fulltext/S2666-3791(25)00644-5
