Formation of functionally distinct mitochondrial subtypes
The mechanisms governing the endoplasmic reticulum-mitochondria contact sites (ERMCSs) regulation and their roles in cellular metabolism is not well understood
The researchers in this study used a reporter of endoplasmic reticulum-mitochondria contact sites (ERMCSs) to identify clinically relevant inducers of ERMCSs.
They identified an FDA-approved drug, fedratinib induces ERMCSs via inhibition of epigenetic modifier BRD4, requiring transcription and mitochondrial bioenergetics for ERMCS formation.
Finally, the authors show BRD4-mediated ERMCSs create distinct intracellular mitochondria subpopulations.
https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00032-8
