Controlling protein translation under stress by ribosome ubiquitination
Ribosomes are modified by a complex ubiquitin code, which controls translation reprogramming and several quality control pathways.
Ubiquitin modification can play a sensor/ signaling role, recruiting proteins with ubiquitin-binding domains to initiate quality control pathways and also regulating ribosomal protein and RNA turnover.
Several layers of regulation occur at the enzymatic, substrate, ubiquitin chain type, and target sites, contributing to the complexity of this ribosome ubiquitin code in eukaryotes.
Emerging evidence suggests that the ubiquitin code mediates crosstalk between signaling pathways that converge at the ribosome, including the integrated stress response and quality control pathways.
Dysregulation of this ribosome ubiquitin code affects cellular physiology and stress tolerance and might contribute to disease states.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00139-2
