How pyruvate transporter hermes regulates autophagy and lifespan?
The plasma membrane pyruvate transporter hrm is required for regulation of the mechanistic target of rapamycin (mTOR) signaling and the activation of autophagy during development.
Loss of hrm results in decreased lifespan, with defects in autophagy in intestine tissues but the mechanism is unclear.
The authors show that loss of hrm results in an increase in reactive oxygen species (ROS), and attenuation of the increase in ROS is sufficient to suppress the effects of hrm loss on autophagy and mTOR signaling.
Thues, the researchers provide mechanistic insight into pyruvate metabolism and autophagy, which influence cell health during development and aging.
https://www.cell.com/cell-reports/fulltext/S2211-1247(26)00652-2
