Connections between the cytoplasm and the nucleolus in ribosome synthesis

Nucleolus  of the cell where biogenesis of ribosomes takes place but ribosomes play a critical role in the mRNA translation into proteins in the cytoplasm.

Ribosome biogenesis is a multi-step resource intensive cellular process and is tightly coordinated with cytoplasmic requirements, energy availability, and the cell cycle through several kinase signaling pathways.

Researchers in this review discuss the role of various kinases and on mammalian target of rapamycin complex 1 (mTORC1) in the ribosome biogenesis and how protein phosphorylation inactivates ribosome biogenesis during mitosis.

They also summarize several factors shared among the mitotic machinery, cytoplasmic organelles, and the nucleolus and discuss  how dysregulated cytoplasmic-nucleolar feedback contributes to the progression of several diseases.

https://www.cell.com/molecular-cell/fulltext/S1097-2765(26)00027-4

https://sciencemission.com/Signaling-to-make-human-ribosomes