Modulating local immunity by tissue-resident regulatory T cells

Tissue-resident regulatory T cells (Tregs) in visceral adipose tissue, skin, intestine, and brain exhibit distinct transcriptional programs and specialized functions that extend beyond immune suppression. 

These tissue-resident Tregs integrate immune tolerance with local tissue remodeling, metabolic regulation, and neural or epithelial repair.

Brain and skin Tregs integrate immune and regenerative programs, coupling inflammation control with neuroprotection and epithelial renewal to sustain tissue integrity and reveal principles of context dependent immune adaptation.

Engineered and tissue-resident Tregs enable precision immune modulation through cytokine, metabolic, and epigenetic reprogramming to achieve durable tolerance and repair.

Understanding tissue-specific cues that stabilize or reprogram Tregs is key to developing next-generation precision Treg therapies.

https://www.cell.com/trends/immunology/fulltext/S1471-4906(25)00309-6

https://sciencemission.com/Tregs---modulators-of-local-immunity