How α-ketoglutaric acid delays aging? 

A tricarboxylic acid cycle metabolite, α-ketoglutaric acid (AKG), plays a key role in longevity.

The researchers reveal that reduced isocitrate dehydrogenase 1 (IDH1) expression during senescence lowers AKG production, accelerating the aging of mesenchymal stem cells (MSCs).  AKG delays MSC senescence by promoting RPS23 hydroxylation, enhancing translation fidelity.

The natural flavonoid scutellarin (Scu), identified as an IDH1 agonist, elevates AKG to delay MSC senescence. In aged mice, Scu improves cognitive function, reduces osteoporosis and skin aging, and suppresses senescence.

https://www.cell.com/cell-reports/fulltext/S2211-1247(25)00688-6

https://sciencemission.com/%CE%B1-ketoglutaric-acid-in-delaying-MSC-senescence