3D genome folding in epigenetic regulation and cellular memory
Epigenetic state dictates nuclear organisation, global genome folding, and certain types of focal chromatin contact.
Chromatin state-driven genome folding is often counteracted by cohesin- and condensin-mediated loop extrusion.
3D organization of the epigenome is tightly linked to cellular identity and provides an additional regulatory layer to safeguard transcriptional states.
Mitosis eliminates all apparent aspects of interphase chromosome organisation, but the epigenetic folding programme is transmitted to daughter cells in a chromosome-intrinsic manner.
Genome folding partially depends on its past state, suggesting that 3D genome organisation contributes to cellular memory.
https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(25)00065-0
