Adipose tissue-targeting nanomedicines to treat obesity

The adipose tissue is the principal organ for energy storage and metabolic regulation, making it a promising target for obesity pharmacotherapy. 

Adipose tissue-targeting nanomedicine holds promise in overcoming limitations arising from traditional obesity pharmacotherapy.

The distinct receptor profiles and physicochemical properties of the adipose tissue allow nanomedicines to target it through both active and passive strategies.

The principal approaches for adipose tissue-specific nanomedicine involve targeting adipocytes for energy balance, macrophages to reduce inflammation, and multiple cell types simultaneously to achieve synergistic effects.

https://www.cell.com/trends/endocrinology-metabolism/fulltext/S1043-2760(25)00055-4

https://sciencemission.com/Adipose-tissue-targeting-nanomedicines