Bile acids at the center of hepato-ocular crosstalk
Hepatic dysfunction with ocular pathology has been linked to dysregulated bile acid metabolism.
Bile acid imbalance has been shown to drive ocular injury along the gut-liver-eye axis through direct cytotoxicity, disruption of retinal and lens homeostasis mediated by FXR and TGR5 signaling, and immune activation and these mechanisms are implicated across a spectrum of conditions, ranging from inborn metabolic disorders to acquired cholestatic diseases.
The researchers in this review discuss translational potential of targeting bile acid homeostasis and summarize emerging therapeutic strategies, including bile acid-based interventions, targeted drug delivery, and microbiome modulation, that aim to restore systemic bile acid balance.
Thus, bile acid homeostasis act as a unifying therapeutic framework for hepato-ocular comorbidities.
https://www.cell.com/iscience/fulltext/S2589-0042(26)00493-1
