ApoE–tau synergy in Alzheimer’s disease
Alzheimer’s disease (AD), is characterized by the accumulation of amyloid-β (Aβ) in senile plaques and abnormally hyperphosphorylated tau proteins in neurofibrillary tangles and is the main cause for dementia in mainly older patients.
Recent evidence suggest tau-mediated neurodegeneration and cognitive decline in AD. APOE being the main genetic risk factor for AD, APOE ε4 and its interaction with tau in Alzheimer’s dementia is not well studied.
Recent evidence suggests apolipoprotein E (apoE), a lipid metabolism protein (encoded by APOE), exacerbates tau-mediated neurodegeneration and tau-related pathology.
The researchers in this review combine current knowledge on the interplay between apoE and tau and highlight the importance of tau in the disease progression. They believe therapeutic strategies targeting apoE-tau axis in tauopathies need to more explored.
https://rupress.org/jem/article/222/10/e20250965/278284/ApoE-calypse-tau-ApoE-tau-synergy-in-Alzheimer-s
