Structural insights into diverse mechanisms of CDK regulation
Cryogenic electron microscopy has extended the scope of structural characterisation of cyclin-dependent kinase (CDK)–cyclin complexes, thereby enhancing our understanding of how CDKs function within large molecular assemblies and how intrinsically disordered sequences within CDK regulators and substrates bind to the CDK–cyclin module.
Greater mechanistic understanding of CDK regulation is identifying routes by which small molecules other than orthosteric (ATP-competitive) inhibitors can modulate CDK activity.
Artificial intelligence systems that predict a protein’s 3D structure from its amino acid sequence are increasingly being employed to generate models of CDK– cyclin complexes as frameworks to seed further experimentation to understand the regulation of the cell cycle and transcription.
https://www.cell.com/trends/biochemical-sciences/fulltext/S0968-0004(25)00299-3
