Circular RNA biogenesis
Circular RNAs (circRNAs) are covalently closed single-stranded RNA molecules. Different subclasses of circRNAs exhibit unique features in their biogenesis.
The intricate formation of circRNAs is orchestrated by various cis-elements and trans-factors.
Trans-factors introduce complexity and precision to circRNA biogenesis because they confer cell type-, tissue-, and disease-specificity that ciselements cannot determine alone.
The in vivo mechanisms of circRNA formation are linked to human diseases, and in vitro synthesized circRNAs are being developed as promising vaccines and drugs.
https://www.cell.com/trends/genetics/fulltext/S0168-9525(25)00283-5
