Diet modulates Vibrio cholerae colonization
Dietary macronutrient type and amount shapes the gut environment and microbiota.
The researchers show that dietary protein sources differentially restrict colonization of the pathogen Vibrio cholerae.
Specific diets like casein, downregulate V. cholerae type VI secretion system (T6SS) expression by altering levels of central flagellar regulator, FlrA.
This leads to the loss of pathogen competitiveness against commensal bacteria like E,coli, as well as alterations in the abundance and composition of the gut microbiota.
Mutations in FlrA restore V. cholerae T6SS expression and abrogate diet-dependent impacts on V. cholerae infection.
https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(25)00464-0
